The New York Yankees will travel up I-95 to play their arch rival, the Boston Red Sox, on Opening Day of the 2010 season,...

The New York Yankees will travel up I-95 to play their arch rival, the Boston Red Sox, on Opening Day of the 2010 season, Major League Baseball announced Tuesday.

The three-game series will kick off April 5, and it marks the first time the two teams have opened the season since 2005 and the 30th time overall that the two have squared off at the start of a season. In addition, the two teams will close out the 2010 regular season with another three-game set in Boston, October 1-3.

It will have been 60 years since the two teams opened and closed the regular season.

“The season opening series and season close out series should only continue to enhance to long-standing rivalry between the two teams and create a valuable ticket on the secondary market,” said Mike Garvie, purchasing manager for ticket brokerage Metro Entertainment, which is owned by TicketNews parent company TicketNetwork.

Fourteen games are scheduled for April 5, with 28 of the 30 teams scheduled to open the season that day. The Baltimore Orioles and the Tampa Bay Rays will open next season in Tampa on April 6.

Other highlights for Opening Day 2010 include the Atlanta Braves hosting the Chicago Cubs and the New York Mets hosting the Florida Marlins.

Also in 2010, the Minnesota Twins will open their new outdoor stadium, Target Field, on April 12, and Yankees will play the Los Angeles Dodgers out West, June 25-27. The Dodgers will also come East to face the Red Sox earlier in the month.

Other interleague game highlights include the Los Angeles Angels traveling to St. Louis to play the Cardinals in May, and the Cincinnati Reds playing their cross-state rival Cleveland Indians the same month.